NeuroscienceJournal of NeuroinflammationPeer-reviewed
iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype
Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie…·Michael Kassiou
This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.
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