Keratinocyte VISTA attenuates UV light-induced skin injury by suppressing cutaneous type I interferon (IFN-I) response
Zachary T. Peters, Lindsay K. Mendyka, J'Voughnn A. Blake, Himanshu Ballav Goswami, Angelique N. Cortez, Grace E. Crossland, Sicong Shan, Elizabeth C. Nowak, Myana Keusch, Mrinal K. Sarkar, Johann Eli Gudjonsson, Christopher M. Burns, Dorothea Torti Barton, Bruce R. Blazar, Tyler Jay Curiel, , Sladjana Skopelja‐Gardner
This study identifies VISTA as a suppressor of UV-induced IFN-I responses in keratinocytes, reducing skin injury in mice and human cells.
JCI Insight · Oct 6, 2026Peer-reviewedImmunology