Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor
Yang Lee, Tony Warne, Rony Nehmé, Shubhi Pandey, Hemlata Dwivedi‐Agnihotri, Madhu Chaturvedi, Patricia C. Edwards, Javier García‐Nafría, Andrew G. W. Leslie, Arun K. Shukla, Christopher G. Tate
This paper determines the cryo-EM structure of the β1AR-βarr1 complex bound to formoterol and compares it to the β1AR-Gs complex, revealing structural differences that inform biased agonism.
Nature · Jun 17, 2020Peer-reviewedMolecular Biology