Author

Javier García‐Nafría

Universidad de ZaragozaORCID 0000-0002-4254-3148Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alicia MansillaiD· 1 shared Andrew G. W. LeslieiD· 1 shared Arun K. ShuklaiD· 1 shared Carlos Requena-TrigueroiD· 1 shared Celia Miró-Rodríguez· 1 shared Christopher G. TateiD· 1 shared Daniel Muñoz-ReyesiD· 1 shared Eugenia UlzurruniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Alicia MansillaORCID

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2 papers

Recent·Most cited

FDA drug repurposing uncovers modulators of dopamine D2 receptor localization via disruption of the NCS-1 interaction

Daniel Muñoz-Reyes, Lorena Aguado, Sandra Arroyo‐Urea, Carlos Requena-Triguero, Sara Pérez-Suárez, Sonia Sánchez-Yepes, Josep Argerich, Celia Miró-Rodríguez, Eugenia Ulzurrun, Eulalia Rodríguez‐Martín, Javier García‐Nafría, Nuria Eugenia Campillo, Alicia Mansilla, María José Sánchez-Barrena

The paper identifies FDA-approved drugs that disrupt the NCS-1/D2R interaction, modulating D2R localization without affecting its signaling.

Journal of Medicinal Chemistry · Nov 10, 2025Peer-reviewedBiochemistry

Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor

Yang Lee, Tony Warne, Rony Nehmé, Shubhi Pandey, Hemlata Dwivedi‐Agnihotri, Madhu Chaturvedi, Patricia C. Edwards, Javier García‐Nafría, Andrew G. W. Leslie, Arun K. Shukla, Christopher G. Tate

This paper determines the cryo-EM structure of the β1AR-βarr1 complex bound to formoterol and compares it to the β1AR-Gs complex, revealing structural differences that inform biased agonism.

Nature · Jun 17, 2020Peer-reviewedMolecular Biology