AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema
Carly Merritt, Rose Griffin, Kristine M. Abo, Joseph E. Kaserman, Pushpinder Bawa, Carlos Villacorta-Martín, Feiya Wang, Michael P. Morley, Michael H. Cho, Maria Ciocca Basil, Maor Sauler, Andrew A. Wilson
This study shows that Z-AAT expression in AT2 cells causes stress responses and increases emphysema risk in AATD.
bioRxiv · Apr 9, 2026 · PreprintCell Biology