Large extracellular vesicles regulate endothelial angiogenic potential via paracrine and autocrine signaling
Crislyn D’Souza‐Schorey, Rose Nguyen, Alanna Sedgwick, Jeffrey S. Schorey, Crislyn D’Souza-Schorey
This study shows that large extracellular vesicles from melanoma promote angiogenic phenotypes in endothelial cells through paracrine and autocrine signaling, contributing to resistance to anti-angiogenic therapies.
Journal of Biological Chemistry · Jan 24, 2026Peer-reviewedCancer Biology