Author

Alanna Sedgwick

University of Notre DameORCID 0000-0002-2386-2063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Crislyn D’Souza-Schorey· 1 shared Crislyn D’Souza‐SchoreyiD· 1 shared Jeffrey S. SchoreyiD· 1 shared Rose Nguyen· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperCancer Biology

Crislyn D’Souza-Schorey

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1 paper

Recent·Most cited

Cancer BiologyJournal of Biological ChemistryPeer-reviewedJan 24, 2026

Large extracellular vesicles regulate endothelial angiogenic potential via paracrine and autocrine signaling

Crislyn D’Souza‐Schorey, Rose Nguyen, Alanna Sedgwick…·Crislyn D’Souza-Schorey

This study shows that large extracellular vesicles from melanoma promote angiogenic phenotypes in endothelial cells through paracrine and autocrine signaling, contributing to resistance to anti-angiogenic therapies.

DOI 10.1016/j.jbc.2026.111193

humanexperimental assay

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