Comprehensive identification of HSP70/HSC70 Chaperone Clients in Human Cells
Seung Woo Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji‐Hoon Lee, Carlos Tadeu Pagani Zanini, Antony Harvey, Jon M. Huibregtse, Peter J. Mueller, Tanya T. Paull
This study identifies HSP70 and HSC70 chaperone clients in human cells using a ubiquitin-mediated tagging strategy, revealing distinct client specificities and stress-induced changes.
PLoS Biology · Jul 20, 2020Peer-reviewedMolecular Biology