Seung Woo Ryu

The paper shows that PARP-driven protein aggregation occurs in ATM and Mre11 deficiency, leading to protein homeostasis loss and cerebellar dysfunction.

This study identifies HSP70 and HSC70 chaperone clients in human cells using a ubiquitin-mediated tagging strategy, revealing distinct client specificities and stress-induced changes.

This study shows that phosphorylation of Hsp70 at Ser151 by Cdk1 during growth reduces its chaperone activity and affects stress responses and prion maintenance.