Tanya T. Paull

Scaling the Dynamics of Coiled Coils

This study uses HS-AFM to visualize coiled coil dynamics in MR complexes, revealing power-law scaling and long relaxation times due to internal friction.

Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

Regulation of transcription patterns, poly-ADP-ribose, and RNA-DNA hybrids by the ATM protein kinase

The paper shows ATM deficiency leads to transcription-associated lesions, affecting cerebellum function and causing neurodegeneration through changes in transcription and PARylation.

Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

The paper shows DNA-PK and TRF2 inhibit MRN resection at blunt telomeres, preventing fusion through alternative end joining.

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

The paper shows that PARP-driven protein aggregation occurs in ATM and Mre11 deficiency, leading to protein homeostasis loss and cerebellar dysfunction.

Comprehensive identification of HSP70/HSC70 Chaperone Clients in Human Cells

This study identifies HSP70 and HSC70 chaperone clients in human cells using a ubiquitin-mediated tagging strategy, revealing distinct client specificities and stress-induced changes.

Growth-regulated Hsp70 phosphorylation regulates stress responses and prion maintenance

This study shows that phosphorylation of Hsp70 at Ser151 by Cdk1 during growth reduces its chaperone activity and affects stress responses and prion maintenance.

ATM and PRDM9 Regulate SPO11-bound Recombination Intermediates During Meiosis

This study directly detects meiotic DSBs and resection in vertebrates using END-seq on mouse spermatocytes, identifying a novel recombination intermediate regulated by ATM and PRDM9.

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

This study shows DNA-PK promotes MRN and phosphorylated CtIP for efficient DNA end processing, facilitating the transition from non-homologous end joining to homologous recombination.

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

This study shows that Sae2/CtIP prevents R-loop accumulation by facilitating their removal, with CtIP nuclease activity playing a critical role in this process.