Ji‐Hoon Lee

The paper shows ATM deficiency leads to transcription-associated lesions, affecting cerebellum function and causing neurodegeneration through changes in transcription and PARylation.

The paper shows that PARP-driven protein aggregation occurs in ATM and Mre11 deficiency, leading to protein homeostasis loss and cerebellar dysfunction.

This study identifies HSP70 and HSC70 chaperone clients in human cells using a ubiquitin-mediated tagging strategy, revealing distinct client specificities and stress-induced changes.

This study shows that Sae2/CtIP prevents R-loop accumulation by facilitating their removal, with CtIP nuclease activity playing a critical role in this process.