ATR promotes genome instability via CENP-A eviction from centromeres under replication stress
Denis Ostapenko, Hang Li, Isabelle Trier, Ross Shamby, Eleanor Zagoren, Carla Becerra Sabrera, Kaelyn Sumigray, Lilian Kabeche
This study shows that ATR promotes genome instability by causing CENP-A eviction from centromeres under replication stress, leading to acentric chromosomes and segregation defects.
bioRxiv · Oct 20, 2025 · PreprintCell Biology