Author

Denis Ostapenko

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:yeast· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Hang LiiD· 2 shared Lilian KabecheiD· 2 shared Mark J. Solomon· 2 shared Alexander NguyeniD· 1 shared Azime Akçaöz-AlasariD· 1 shared Bünyamin AkgüliD· 1 shared Carla Becerra Sabrera· 1 shared Carlos Andrés Ramírez Parrado· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Hang LiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

METTL3 promotes cell cycle progression via activation of transcriptional elongation.

Azime Akçaöz-Alasar, Yanhua Wang, Hang Li, Denis Ostapenko, Carlos Andrés Ramírez Parrado, Daniela Villalobos, Hengyi Li, Prajwal Chaitanya Boddu, Alexander Nguyen, Marcelo Pérez-Pepe, Pénélope Darnat, Bünyamin Akgül, Manoj M. Pillai, Yansheng Liu, Lilian Kabeche, Claudio R. Alarcón

The paper shows that METTL3 phosphorylation by CDK1 promotes transcriptional elongation and cell cycle progression through the m6A/7SK/P-TEFb axis.

Molecular Cell · Jul 31, 2026Peer-reviewedMolecular Biology

ATR promotes genome instability via CENP-A eviction from centromeres under replication stress

Denis Ostapenko, Hang Li, Isabelle Trier, Ross Shamby, Eleanor Zagoren, Carla Becerra Sabrera, Kaelyn Sumigray, Lilian Kabeche

This study shows that ATR promotes genome instability by causing CENP-A eviction from centromeres under replication stress, leading to acentric chromosomes and segregation defects.

bioRxiv · Oct 20, 2025 · PreprintCell Biology

APCCdh1-mediated degradation of Cdh1 is necessary for faithful meiotic chromosome segregation in S. cerevisiae

Denis Ostapenko, Mark J. Solomon

This study shows that APCCdh1-mediated degradation of Cdh1 is essential for proper meiotic chromosome segregation in S. cerevisiae.

bioRxiv · Jul 1, 2024 · PreprintCell Biology

APC/CCdh1-mediated degradation of Cdh1 during meiosis in S. cerevisiae

Denis Ostapenko, Mark J. Solomon

The paper investigates APC/CCdh1-mediated Cdh1 degradation during meiosis in S. cerevisiae, showing it occurs in response to glucose starvation and requires SNF1 kinase activity.

bioRxiv · Jun 28, 2018 · PreprintCell Biology