Kaelyn Sumigray

This study identifies BLIMP1 and CASZ1 as mutually repressive transcription factors that regulate intestinal enterocyte maturation during weaning and corticosteroid-induced maturation.

The paper uses single-cell RNA sequencing to analyze mutant phenotypes of epigenetic regulators in mouse embryos, revealing how these regulators partition the genome based on developmental and evolutionary constraints.

This study identifies the planar cell polarity pathway as coordinating epithelial migration and functional zonation during intestinal development.

This study uses a deep-learning model to analyze scRNA-seq data and identifies how folate deficiency disrupts metabolic transitions in developing mouse neural ectoderm, leading to morphological defects.

This study shows that epidermal stem cell proliferative capacity remains unaffected by fibroblast depletion in both adult and neonatal skin, highlighting robust compensatory mechanisms.

The paper shows that a mechanical tension gradient encoded by tissue geometry drives epithelial renewal and cell movement in the intestine.

The paper shows that humanized Traf6 promoter sequences in mice affect immune responses but not fertility, revealing distinct roles for germ and immune cells in gene regulatory evolution.

This study shows that ATR promotes genome instability by causing CENP-A eviction from centromeres under replication stress, leading to acentric chromosomes and segregation defects.

This study shows that epidermal stem cells regulate periderm injury repair by forming specialized intercellular junctions through interactions with the extracellular matrix.

The paper identifies a rare secretory cell type in the intestine, CHEs, and shows that a second wave of Notch signaling is required for their specification.

The paper identifies CFTR High Expresser cells in rat small intestine as pH-sensing neuropod cells and links them to CF disease pathogenesis.

This paper identifies mechanisms by which Rap1 regulates Canoe/Afadin localization and adherens junction positioning to establish apical-basal polarity in Drosophila embryos.