Lilian Kabeche

The paper shows that METTL3 phosphorylation by CDK1 promotes transcriptional elongation and cell cycle progression through the m6A/7SK/P-TEFb axis.

The paper identifies Kacme as a histone modification marking accessible chromatin that resists compaction, particularly at regulatory regions and insulator elements.

This study identifies a novel cytoplasmic function of the KSHV packaging factor ORF68, dependent on its interaction with the viral tyrosine kinase ORF21.

This study identifies JAK1 as a driver of tumor cell radiosensitivity and shows that Kif18a inhibition can counteract therapeutic resistance by exacerbating mitotic stress.

This study shows that ATR promotes genome instability by causing CENP-A eviction from centromeres under replication stress, leading to acentric chromosomes and segregation defects.

This study identifies Chk2 as a regulator of PLK1 activity during mitosis, showing its role in preventing chromosome segregation errors and genome instability.