The Aging Brain Matrix: Cross-Species Evidence Linking FREM3 to Brain and Cognitive Aging
Kevan P. Clifford, Thomas D. Prévot, Akiko Sumitomo, Srija Das, Yashika Bansal, Michael D Marcotte, Runhao Zhou, Jonas H.M. Yeung, Megan Ding, Daniel Felsky, Brian J. Nieman, Mounira Banasr, Etienne L. Sibille, Toshifumi Tomoda, Yuliya S. Nikolova
This study links the FREM3 gene to brain and cognitive aging using cross-species evidence from mice and humans, showing reduced brain volume and cognitive performance in Frem3 knockout mice and lower FREM3-GReX associated with reduced brain surface area and cognitive performance in humans.
bioRxiv · Oct 28, 2026 · PreprintNeuroscience