Mounira Banasr

This study links the FREM3 gene to brain and cognitive aging using cross-species evidence from mice and humans, showing reduced brain volume and cognitive performance in Frem3 knockout mice and lower FREM3-GReX associated with reduced brain surface area and cognitive performance in humans.

This study investigates the role of IFN-γ receptor signaling in SST interneurons, showing it supports normal behavior and molecular homeostasis while mediating inflammation-induced deficits.

This study investigates how acute and chronic stress affect neuronal and astroglial activity and communication in the prefrontal cortex, finding that chronic stress impairs neuron-astroglia coupling and is linked to behavioral deficits.

This study examines age-related changes in brain structure and cognition in mice, finding volume and network differences associated with maturation and aging.

This study shows that depletion of PFC GFAP+ astroglia induces anhedonia-like behavior, while their activation reverses stress-induced anhedonia, highlighting their role in depression.

The paper investigates transcriptomic changes in cortical microcircuit cell types under chronic stress and finds coordinated shifts in gene expression patterns associated with altered excitation-inhibition balance.

This study shows chronic amygdala hyperactivation in mice increases anxiety and may worsen stress-induced anxiety but does not cause depressive-like behaviors.

This study examines how chronic stress affects behavior and molecular markers in mice, showing gender-specific differences in molecular responses and behavioral outcomes.

This study shows that chronic stress increases neuronal activation in specific brain regions in response to acute stress, which correlates with behavioral deficits in mice.

This study identifies three novel GABAA receptor modulators that show anxiolytic, antidepressant, and pro-cognitive effects in mice, unlike diazepam.