A Platinum Butterfly Effect: Small Changes Turn an Anticancer Drug into a Non-toxic Metalloantibiotic with In Vivo Efficacy
Çağrı Özsan, Ann-Britt Schäfer, Abdul Akhir, Obed Akwasi Aning, Sofia Fulgencio, Rahul Maitra, Rupa Rani, Deepanshi Saxena, Fredrik Westerlund, Sidharth Chopra, Michaela Wenzel, Angelo Frei
This paper describes the development of a platinum-based antibiotic, Pt1, which shows potent antibacterial activity against resistant Staphylococcus aureus strains and demonstrates in vivo efficacy in a murine infection model.
npj Antimicrobials and Resistance · May 8, 2026Peer-reviewedMicrobiology