Resolution of collapsed forks is separate from completion of DNA synthesis
Sara C. Conwell, Steven N Dahmen, Matthew T. Cranford, Ruthie Mulvaney, David T Long, David Cortez, James M. Dewar
The paper shows that replication fork collapse at SSBs leads to seDSBs resolved by homologous recombination, but DNA synthesis downstream is inefficient, while deDSBs allow efficient synthesis without recombination.
bioRxiv · Mar 3, 2025 · PreprintBiochemistry