Matthew T. Cranford

Leading and lagging strand abasic sites differentially affect vertebrate replisome progression but involve analogous bypass mechanisms

The paper investigates how abasic sites on leading and lagging strands affect replisome progression and bypass mechanisms in Xenopus egg extracts, showing distinct stalling effects but similar reliance on translesion synthesis.

Resolution of collapsed forks is separate from completion of DNA synthesis

The paper shows that replication fork collapse at SSBs leads to seDSBs resolved by homologous recombination, but DNA synthesis downstream is inefficient, while deDSBs allow efficient synthesis without recombination.