Author

Sara C. Conwell

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:Xenopus· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

James M. DewariD· 2 shared David CorteziD· 1 shared David T Long· 1 shared Emma Grogan· 1 shared Matthew T. CranfordiD· 1 shared Obehi E Ozua· 1 shared Ruthie Mulvaney· 1 shared Steven N Dahmen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

James M. DewarORCID

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2 papers

Recent·Most cited

Strand-independent degradation of uncoupled forks by EXO1 activates ATR and restrains fork progression

Emma Grogan, Obehi E Ozua, Tamar Kavlashvili, Sara C. Conwell, James M. Dewar

This study shows EXO1-mediated strand-independent degradation of uncoupled replication forks activates ATR and limits fork progression in Xenopus egg extracts.

bioRxiv · Jul 2, 2026 · PreprintBiochemistry

Resolution of collapsed forks is separate from completion of DNA synthesis

Sara C. Conwell, Steven N Dahmen, Matthew T. Cranford, Ruthie Mulvaney, David T Long, David Cortez, James M. Dewar

The paper shows that replication fork collapse at SSBs leads to seDSBs resolved by homologous recombination, but DNA synthesis downstream is inefficient, while deDSBs allow efficient synthesis without recombination.

bioRxiv · Mar 3, 2025 · PreprintBiochemistry