Author

Fangwei Leng

Boston Children's HospitalORCID 0009-0004-2827-2523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Sun HuriD· 2 shared Wenxiang ZhangiD· 2 shared Xi WangiD· 2 shared Cuidie Wang· 1 shared Haribabu ArthanariiD· 1 shared Raquel Merino‐UrteagaiD· 1 shared Ryan Clark· 1 shared Taekjip HaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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2 shared papersBioinformatics

Sun HurORCID

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2 papers

Recent·Most cited

BioinformaticsCell ReportsPeer-reviewedNov 27, 2025

FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites

Fangwei Leng, Ryan Clark, Wenxiang Zhang…·Sun Hur

The paper shows FoxP3 forms head-to-head dimers and stabilizes multimerization on microsatellites in Tregs, revealing a dual DNA-binding mode.

2 citations

humanDNA methylation

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BiochemistryMolecular CellPeer-reviewedApr 1, 2025

Ultrastable and Versatile FoxP3 Ensembles on Microsatellites

Fangwei Leng, Raquel Merino‐Urteaga, Xi Wang…·Sun Hur

This study shows FoxP3 forms different supramolecular structures on microsatellites, enabling it to bridge DNA duplexes and coordinate genomic loci, with nucleosomes aiding assembly.

4 citations

experimental assaymicroscopy & imaging analysis

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