Author

Ryan Talcoff

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Elizabeth M. BradshawiD· 2 shared Estela Área-GómeziD· 2 shared A. Yadav· 1 shared Andrew F. TeichiD· 1 shared Benjamin N. Hoover· 1 shared Dallin DressmaniD· 1 shared G. Martins· 1 shared J. Mares· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Elizabeth M. BradshawORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells

Khushbu Kabra, Dallin Dressman, Ryan Talcoff, Maedot Yidenk, Olivia M. Rifai, Benjamin N. Hoover, Neil A. Shneider, Wassim Elyaman, Estela Área-Gómez, Elizabeth M. Bradshaw

This study shows that loss of nuclear TDP-43 in microglia-like cells disrupts lipid metabolism, leading to increased lipid droplets, phagocytosis, and inflammation, which can be mitigated by DGAT inhibitors.

bioRxiv · Sep 17, 2025 · PreprintNeuroscience

RNA- and ATAC-sequencing Reveals a Unique CD83+ Microglial Population Focally Depleted in Parkinson's Disease

Zena K. Chatila, A. Yadav, J. Mares, Xena E. Flowers, Taekyung Yun, M. Rashid, Ryan Talcoff, Z. Pelly, Ya Zhang, Philip L. De Jager, Andrew F. Teich, Rui M. Costa, Estela Área-Gómez, G. Martins, Roy N. Alcalay, , Serge Przedborski

The paper uses single-nucleus RNA- and ATAC-sequencing to identify a CD83+ microglial subpopulation depleted in Parkinson's disease, with implications for neuronal vulnerability.

bioRxiv · May 17, 2023 · PreprintNeuroscience