Author

S. A. Fromm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Ibanez de Opakua· 1 shared A. L. Yokom· 1 shared B. Wolozin· 1 shared D. Chatterjee· 1 shared J. A. Purslow· 1 shared J. H. Hurley· 1 shared M. Zachrdla· 1 shared M. Zweckstetter· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. Ibanez de Opakua

Mutual co-authors in cluster

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2 papers

Recent·Most cited

GSK3β phosphorylation catalyzes the aggregation of Tau into Alzheimer's disease-like amyloid strain

P. Chakraborty, A. Ibanez de Opakua, J. A. Purslow, S. A. Fromm, D. Chatterjee, M. Zachrdla, S. Puri, B. Wolozin, M. Zweckstetter

This study shows GSK3β phosphorylation drives tau aggregation into Alzheimer's-like amyloid strains through enhanced phase separation.

bioRxiv · Dec 19, 2023 · PreprintBiophysics

Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation

R. M. Jansen, R. Peruzzo, S. A. Fromm, A. L. Yokom, R. Zoncu, J. H. Hurley

The paper determines the cryo-EM structure of the active FLCN complex, revealing how it selectively regulates mTORC1 substrates TFEB and TFE3.

bioRxiv · Jun 28, 2022 · PreprintBiochemistry