M. J. McConville

Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum

This study shows that apicoplast-derived isoprenoids are essential for GPI anchor biosynthesis in Plasmodium falciparum, which is critical for parasite egress and invasion.

Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose

This paper identifies a novel bacterial pathway for sulfofucose catabolism in Paracoccus wurundjeri, involving a sulfofucolytic Entner-Doudoroff pathway and subsequent biomineralization to sulfite.

Remodelling of carbon metabolism during sulfoglycolysis in Escherichia coli

This study identifies metabolic changes in Escherichia coli when grown on sulfoquinovose versus glucose, revealing increased storage carbohydrate synthesis and reduced TCA cycle flux.

Coordinated Action of Multiple Transporters in the Acquisition of Essential Cationic Amino Acids by the Intracellular Parasite Toxoplasma gondii

This study identifies TgApiAT6-1 as a second arginine transporter in Toxoplasma gondii, showing it mediates both lysine and arginine uptake and is essential for parasite proliferation.

Microbe-metabolite associations linked to the rebounding murine gut microbiome post-colonization with vancomycin resistant Enterococcus faecium

This study investigates how the gut microbiome changes in mice after colonization with vancomycin-resistant Enterococcus faecium, identifying metabolite associations linked to bacterial shifts.

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

This paper identifies a sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum that allows growth on sulfoquinovose, producing sulfolactate and contributing to bacterial persistence in soil.

Neuronal-specific function of hTim8a in Complex IV assembly provides insight into the molecular mechanism underlying Mohr-Tranebjaerg syndrome

This study identifies hTim8a's role in neuronal Complex IV assembly and shows how its loss causes oxidative stress and apoptosis, contributing to Mohr-Tranebjaerg syndrome.

Hookworm-derived small molecule extracts suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes

This study identifies anti-inflammatory small molecules from hookworms that reduce colitis pathology in mice and inhibit cytokine secretion in human leukocytes.

The metabolic repair enzyme phospho-glycolate phosphatase regulates central carbon metabolism and fosmidomycin sensitivity in Plasmodium falciparum

This study identifies phospho-glycolate phosphatase (PfPGP) as a regulator of central carbon metabolism in Plasmodium falciparum, showing its role in metabolite homeostasis and drug sensitivity.

Characterization of the apicomplexan amino acid transporter (ApiAT) family in Toxoplasma gondii

The paper identifies and characterizes the ApiAT family of amino acid transporters in Toxoplasma gondii, showing their role in amino acid scavenging and parasite virulence.