Author

M. J. Boucher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:Arabidopsis· 1 Organism:C. elegans· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

E. Yeh· 2 shared A. Ju· 1 shared A. Lal· 1 shared A.-C. Uhlemann· 1 shared B. H. Stokes· 1 shared C. J. Schulze· 1 shared D. A. Fidock· 1 shared E. A. Gaylord· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

E. Yeh

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Author profile →

5 papers

Recent·Most cited

Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging

M. Y. Huang, M. B. Joshi, M. J. Boucher, S. Lee, L. C. Loza, E. A. Gaylord, T. L. Doering, H. D. Madhani

This paper optimizes Cas9 for Cryptococcus neoformans to enable efficient gene editing with short homology arms.

bioRxiv · Jun 30, 2021Microbiology

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

E. Yoo, C. J. Schulze, B. H. Stokes, O. Onguka, T. Yeo, S. Mok, N. F. Gnadig, Y. Zhou, K. Kurita, I. T. Foe, S. M. Terrell, M. J. Boucher, P. Cieplak, R. G. Linington, J. Z. Long, , M. Bogyo

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

bioRxiv · Nov 1, 2019Cell Biology

Structure-function analysis reveals a DNA polymerization-independent role for mitochondrial DNA polymerase IC in African trypanosomes.

J. C. Miller, S. B. Delzell, J. Concepcion-Acevedo, M. J. Boucher, M. M. Klingbeil

The paper identifies a DNA polymerase with a role in mitochondrial DNA segregation in African trypanosomes, independent of its polymerization activity.

bioRxiv · Aug 9, 2019 · PreprintMicrobiology

Evidence that disruption of apicoplast protein import in malaria parasites evades delayed-death growth inhibition

M. J. Boucher, E. Yeh

This study shows that disrupting apicoplast protein import in malaria parasites avoids delayed-death growth inhibition, suggesting potential for developing fast-acting antimalarials.

bioRxiv · Sep 21, 2018Microbiology

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

M. J. Boucher, S. Ghosh, L. Zhang, A. Lal, S. W. Jang, A. Ju, S. Zhang, X. Wang, S. A. Ralph, J. Zou, J. E. Elias, E. Yeh

The paper combines proteomics and machine learning to generate a high-confidence apicoplast proteome in malaria parasites, identifying 346 proteins and validating novel functions.

bioRxiv · Jul 28, 2018Microbiology