Author

S. A. Rocco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. d. S. Justo-Junior· 1 shared A. G. Coyne· 1 shared A. Hammer· 1 shared C. Abell· 1 shared C. Harris· 1 shared C. Perecin· 1 shared C. v. Z. de Valega Negrao· 1 shared D. Adamoski· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. d. S. Justo-Junior

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Iron Oxide Nanoparticles Coated with Biodegradable Block-Copolymer PDMAEMA-b-PMPC and Functionalized with Aptamer for HER2 Breast Cancer Cell Identification

C. v. Z. de Valega Negrao, N. N. P. Cerize, A. d. S. Justo-Junior, R. B. Liszbinski, G. P. Meneguetti, L. Araujo, S. A. Rocco, K. d. A. Goncalves, D. R. Cornejo, P. Leo, C. Perecin, D. Adamoski, S. M. G. Dias

This paper develops a novel hybrid nanoparticle functionalized with a DNA aptamer for HER2 breast cancer cell identification, showing high specificity and low toxicity.

bioRxiv · Jun 6, 2023 · PreprintCancer Biology

Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis

J. A. Ribeiro, A. Hammer, G. A. L. Zuniga, S. M. Chavez-Pacheco, P. Tyrakis, G. S. de Oliveira, T. Kirkman, J. El Bakali, S. A. Rocco, M. L. Sforca, R. Parise-Filho, A. G. Coyne, T. L. Blundell, C. Abell, M. V. B. Dias

This study uses fragment-based drug discovery to identify novel chemical scaffolds targeting Mycobacterium tuberculosis DHFR, revealing a new binding mode and low micromolar affinity compounds.

bioRxiv · Mar 30, 2020Biochemistry

Cadmium exposure inhibits branching morphogenesis and causes alterations consistent with HIF-1α inhibition in human primary breast organoids

S. A. Rocco, L. Koneva, L. Y. M. Middleton, T. Thong, S. Solanki, S. Karram, K. Nambunmee, C. Harris, L. S. Rozek, M. A. Sartor, Y. M. Shah, J. Colacino

This study shows cadmium exposure inhibits branching morphogenesis and HIF-1α activity in human breast organoids, suggesting it disrupts mammary gland development rather than promoting cancer.

bioRxiv · Nov 3, 2017Pharmacology & Toxicology