Author

P. Tyrakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. G. Coyne· 1 shared A. Guislain· 1 shared A. Hammer· 1 shared A. Palazon· 1 shared B. Nicolet· 1 shared C. Abell· 1 shared C. Jorgensen· 1 shared D. Bargiela· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. G. Coyne

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Author profile →

2 papers

Recent·Most cited

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

I. P. Foskolou, P. P. Cunha, E. Minogue, B. Nicolet, A. Guislain, C. Jorgensen, N. D. Zandhuis, L. Barbieri, D. Bargiela, D. Nathanael, P. Tyrakis, A. Palazon, M. Wolkers, R. S. Johnson

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

bioRxiv · Aug 18, 2022Immunology

Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis

J. A. Ribeiro, A. Hammer, G. A. L. Zuniga, S. M. Chavez-Pacheco, P. Tyrakis, G. S. de Oliveira, T. Kirkman, J. El Bakali, S. A. Rocco, M. L. Sforca, R. Parise-Filho, A. G. Coyne, T. L. Blundell, C. Abell, M. V. B. Dias

This study uses fragment-based drug discovery to identify novel chemical scaffolds targeting Mycobacterium tuberculosis DHFR, revealing a new binding mode and low micromolar affinity compounds.

bioRxiv · Mar 30, 2020Biochemistry