Author

S. Afshar-Sterle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Ernst· 2 shared A. Boussioutas· 1 shared A. Dhillon· 1 shared A. I. Azimpour· 1 shared A. L. Chand· 1 shared A. L. E. Carli· 1 shared D. Baloyan· 1 shared E. F. Lee· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

M. Ernst

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Author profile →

2 papers

Recent·Most cited

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

S. Afshar-Sterle, A. L. E. Carli, R. O'Keefe, J. Tse, S. Fischer, A. I. Azimpour, D. Baloyan, L. Elias, P. Thilakasiri, O. Patel, F. M. Ferguson, M. F. Eissmann, A. L. Chand, N. S. Gray, R. Busuttil, , M. Buchert

This study identifies DCLK1 kinase activity as a driver of gastric cancer progression by reprogramming the tumor stroma and promoting invasiveness and metastasis.

bioRxiv · Apr 21, 2022 · PreprintCancer Biology

Dual MAPK and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death

L. J. Jenkins, I. Y. Luk, M. Palmieri, W. D. Fairlie, E. F. Lee, K. L. Schoffer, T. Tan, I. Ng, N. Vukelic, J. W. Tse, R. Nightingale, Z. Alam, G. Iatropoulos, M. Ernst, S. Afshar-Sterle, , J. M. Mariadason

This study shows that combining MEK/ERK and HDAC inhibition synergistically induces apoptosis in colorectal cancer cells and organoids, and can be tailored to specific MAPK genotypes.

bioRxiv · Feb 15, 2021 · PreprintCancer Biology