Author

M. Buchert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

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Research Focus:cancer & tumor microenvironment· 5 Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:development & morphogenesis· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Ernst· 4 shared M. F. Eissmann· 4 shared D. Baloyan· 3 shared A. R. Poh· 2 shared C. M. Reehorst· 2 shared D. S. Williams· 2 shared I. Y. Luk· 2 shared R. Busuttil· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

M. Ernst

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

A. Huber, A. H. Allam, C. Dijkstra, S. Thiem, J. Huynh, A. R. Poh, J. Konecnik, S. P. Jacob, R. Busuttil, Y. Liao, D. Chasinga, W. Shi, M. G. Alorro, S. Forrow, D. V. F. Tauriello, , M. F. Eissmann

This study identifies IL6/STAT3 signaling as a therapeutic target for TP53-mutant gastric cancer by showing its role in metastatic progression driven by mutant Trp53.

bioRxiv · Apr 22, 2024Cancer Biology

Beclin1 is essential for intestinal homeostasis.

S. Tran, J. Juliani, T. J. Harris, M. Evangelista, J. Ratcliffe, S. L. Ellis, D. Baloyan, C. M. Reehorst, R. Nightingale, I. Y. Luk, L. J. Jenkins, S. Ghilas, M. H. Yakou, C. Inguanti, C. Johnson, , E. F. Lee

This study shows BECLIN1 is critical for intestinal homeostasis, as its deletion in adult mice causes fatal enteritis with compromised gut barrier integrity and morphological abnormalities.

bioRxiv · Jun 14, 2023 · PreprintCell Biology

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

S. Afshar-Sterle, A. L. E. Carli, R. O'Keefe, J. Tse, S. Fischer, A. I. Azimpour, D. Baloyan, L. Elias, P. Thilakasiri, O. Patel, F. M. Ferguson, M. F. Eissmann, A. L. Chand, N. S. Gray, R. Busuttil, , M. Buchert

This study identifies DCLK1 kinase activity as a driver of gastric cancer progression by reprogramming the tumor stroma and promoting invasiveness and metastasis.

bioRxiv · Apr 21, 2022 · PreprintCancer Biology

Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in mice

R. N. O'Keefe, A. Carli, D. Baloyan, S. Sterle, M. F. Eissmann, A. R. Poh, C. Seillet, R. M. Locksley, M. M. Ernst, M. Buchert

The paper shows that inhibiting the tuft cell/ILC2 axis reduces gastric tumor growth in mice by disrupting a circuit that promotes tumor formation.

bioRxiv · Feb 16, 2022Cancer Biology

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

K. Doggett, K. J. Morgan, S. Mieruszynski, B. B. Williams, A. M. Olthof, A. L. Garnham, M. J. G. Milevskiy, L. Whitehead, J. Coates, M. Buchert, R. J. O'Donoghue, T. E. Hall, Z. Gong, T. L. Putoczki, M. Ernst, , J. K. Heath

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

bioRxiv · Dec 9, 2021Cancer Biology

EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis

C. M. Reehorst, R. Nightingale, I. Y. Luk, L. Jenkins, F. Koentgen, D. S. Williams, C. Darido, F. Tan, H. Anderton, M. Chopin, K. Schoffer, M. F. Eissmann, M. Buchert, D. Mouradov, O. M. Sieber, , J. M. Mariadason

This study shows that EHF is essential for epidermal and colonic epithelial homeostasis and acts as a tumor suppressor in colorectal cancer.

bioRxiv · Mar 1, 2021Cell Biology