Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis
B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold
This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.
bioRxiv · Mar 3, 2020 · PreprintCancer Biology