Author

M. E. Pacold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. M. Sabatini· 2 shared A. Ali· 1 shared A. C. Kimmelman· 1 shared A. Friedman· 1 shared A. Gilsrud· 1 shared A. Luengo· 1 shared A. Madruga· 1 shared A. Plasger· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

D. M. Sabatini

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Author profile →

4 papers

Recent·Most cited

DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy

H.-P. Lin, J. D. Petersen, A. Gilsrud, A. Madruga, T. M. D'Silva, X. Huang, M. K. Shammas, N. P. Randolph, Y. Li, D. R. Jones, M. E. Pacold, D. Narendra

The paper identifies DELE1's role in promoting translation-associated homeostasis, growth, and survival in mitochondrial myopathy through the mt-ISR pathway.

bioRxiv · Feb 29, 2024Cell Biology

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

L. Wu, K. E. R. Hollinshead, Y. Hao, C. Au, L. Kroehling, C. Ng, W.-y. Lin, D. Li, H. M. Silva, J. Shin, J. J. Lafaille, R. Possemato, M. E. Pacold, T. Y. Papagiannakopoulos, A. C. Kimmelman, , D. R. Littman

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

bioRxiv · Jun 10, 2020Immunology

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

bioRxiv · Mar 3, 2020 · PreprintCancer Biology

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

J. M. Rohde, K. R. Brimacombe, L. Liu, M. E. Pacold, A. Yasgar, D. M. Cheff, T. D. Lee, G. Rai, B. Baljinnyam, Z. Li, A. Simeonov, M. D. Hall, M. Shen, D. M. Sabatini, M. B. Boxer

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

Bioorganic & Medicinal Chemistry · May 1, 2018Peer-reviewedCancer Biology