Antibacterial potency of Type VI amidase effector toxins is dependent on substrate topology and cellular context
A. Radkov, A. L. Sapiro, S. Flores, C. Henderson, H. Saunders, R. Kim, S. Massa, S. Thompson, C. Mateusiak, J. Biboy, Z. Zhao, L. M. Starita, W. Hatleberg, W. Vollmer, A. B. Russell, , S. Chou
This study identifies functional determinants of Tae1, a bacterial T6SS amidase toxin, showing that its antimicrobial potency depends on substrate topology and cellular context.
bioRxiv · Feb 15, 2022Biochemistry