Author

A. L. Sapiro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Ecology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Chou· 4 shared A. Radkov· 2 shared B. W. Zaro· 2 shared C. Mateusiak· 2 shared R. F. Volk· 2 shared Z. Zhao· 2 shared A. B. Russell· 1 shared A. Swei· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

S. Chou

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi

M. C. Tal, P. S. Hansen, H. A. Ogasawara, Q. Feng, R. F. Volk, B. Lee, S. E. Casebeer, G. S. Blacker, M. Shoham, S. D. Galloway, A. L. Sapiro, L.-B. T. Dulgeroff, T. Raveh, V. R. Pothineni, H.-H. S. Potula, , B. W. Zaro

This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.

bioRxiv · Apr 29, 2024 · PreprintImmunology

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

A. L. Sapiro, B. M. Hayes, R. F. Volk, J. Y. Zhang, D. M. Brooks, C. Martyn, A. Radkov, Z. Zhao, M. Kinnersley, P. R. Secor, B. W. Zaro, S. Chou

This study maps transcriptome changes in Borrelia burgdorferi during tick-borne transmission by analyzing gene expression over four days in ticks.

bioRxiv · Nov 9, 2022 · PreprintMicrobiology

Antibacterial potency of Type VI amidase effector toxins is dependent on substrate topology and cellular context

A. Radkov, A. L. Sapiro, S. Flores, C. Henderson, H. Saunders, R. Kim, S. Massa, S. Thompson, C. Mateusiak, J. Biboy, Z. Zhao, L. M. Starita, W. Hatleberg, W. Vollmer, A. B. Russell, , S. Chou

This study identifies functional determinants of Tae1, a bacterial T6SS amidase toxin, showing that its antimicrobial potency depends on substrate topology and cellular context.

bioRxiv · Feb 15, 2022Biochemistry

Lizard feeding enhances Ixodes pacificus vector competency

K. Ring, L. Couper, A. L. Sapiro, F. Yarza, F. Yang, K. Clay, C. Mateusiak, S. Chou, A. Swei

This study shows that feeding Ixodes pacificus larvae on lizards increases their likelihood of becoming infected with Borrelia burgdorferi compared to feeding on mice, and alters gene regulation.

bioRxiv · Apr 28, 2021 · PreprintEcology