S. H. Baik

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

The paper identifies the CUL5 ubiquitin ligase complex as a mediator of resistance to MCL1 and CDK9 inhibitors in lung cancer cells by regulating pro-apoptotic proteins.

Disabling Cas9 by an anti-CRISPR DNA mimic

This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.