Author

J.-J. Liu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

B. J. Rauch· 2 shared E. Nogales· 2 shared F. Jiang· 2 shared J. A. Doudna· 2 shared J. Bondy-Denomy· 2 shared B. A. Osuna· 1 shared C. Ma· 1 shared D. Li· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

B. J. Rauch

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Endophilin A1 promotes Actin Polymerization in response to Ca2+/calmodulin to Initiate Structural Plasticity of Dendritic Spines

J.-J. Liu, Y. Yang, J. Chen, X. Chen, D. Li, J. He, S. Zhao, X. Yang, S. Deng, D. Wang, Z. Guo, S. Zhu, D. Li, C. Ma, X. Liang, Y. S. Shi

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

bioRxiv · May 7, 2020Cell Biology

Temperature-responsive competitive inhibition of CRISPR-Cas9

F. Jiang, J.-J. Liu, B. A. Osuna, M. Xu, J. D. Berry, B. J. Rauch, E. Nogales, J. Bondy-Denomy, J. A. Doudna

This study shows AcrIIA2 and AcrIIA2b inhibit Cas9 DNA binding through structural occlusion, with temperature-dependent effects due to structural and environmental differences.

bioRxiv · Sep 3, 2018Biochemistry

Disabling Cas9 by an anti-CRISPR DNA mimic

J. Shing, F. Jiang, J.-J. Liu, N. L. Bray, B. J. Rauch, S. H. Baik, E. Nogales, J. Bondy-Denomy, J. E. Corn, J. A. Doudna

This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.

bioRxiv · Apr 23, 2017Biochemistry