Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
2 papers
Recent·Most cited
F. Jiang, J.-J. Liu, B. A. Osuna, M. Xu, J. D. Berry, B. J. Rauch, E. Nogales, J. Bondy-Denomy, J. A. Doudna
This study shows AcrIIA2 and AcrIIA2b inhibit Cas9 DNA binding through structural occlusion, with temperature-dependent effects due to structural and environmental differences.
bioRxiv · Sep 3, 2018Biochemistry
J. Shing, F. Jiang, J.-J. Liu, N. L. Bray, B. J. Rauch, S. H. Baik, E. Nogales, J. Bondy-Denomy, J. E. Corn, J. A. Doudna
This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.
bioRxiv · Apr 23, 2017Biochemistry