S. Haas

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

Multiple myeloma long-term survivors display sustained immune alterations decades after first line therapy

This study examines immune changes in multiple myeloma survivors years after treatment, finding sustained immune alterations linked to residual disease and therapy.

CREID- A ChemoReceptor-Effector Interaction Database

CREID provides a database of bacterial chemoreceptor-effector interactions, offering insights into bacterial sensing mechanisms and applications for biosensor development.

Single-cell time series analysis reveals the dynamics of in vivo HSPC responses to inflammation

The paper uses single-cell time series analysis to study HSPC responses to IFN treatment, revealing heterogeneous gene responses and reduced myeloid differentiation.

Co-option of the transcription factor SALL1 in mole ovotestis formation

The paper identifies SALL1 as a co-opted gene in mole ovotestis formation through comparative epigenetic and transcriptional analyses, showing enhancer evolution drives testicular tissue development.

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

CloneTracer identifies differentiation routes in AML by adding clonal resolution to single-cell RNA-seq data, revealing disease-defining compartments and therapy response mechanisms.

Formation, collective motion, and merging of macroscopicbacterial aggregates

This study examines the formation and dynamics of bacterial aggregates in Enterobacter cloacae, revealing a new mechanism of collective motility driven by density-dependent motility changes.

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

The paper generates single-cell proteo-genomic reference maps of human hematopoietic cells to enable precise cell state purification and functional profiling.

Avalanches During Epithelial Tissue Growth; Uniform Growth and a Drosophila Eye Disc Model

The paper identifies cellular flow avalanches in a Drosophila eye disc model, showing they regulate tissue growth and follow a power law distribution.

Hematopoietic stem cells fail to regenerate following inflammatory challenge.

This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.