Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
S. Haji, T. Ito, C. Guenther, M. Nakano, T. Shimizu, D. Mori, Y. Chiba, M. Tanaka, S. K. Mishra, J. A. Willment, G. D. Brown, M. Nagae, S. Yamasaki
This study identifies human Dectin-1 as a ligand for CLEC-2, showing its O-glycosylation enables it to function as a physiological ligand for immune regulation.
eLife · Dec 8, 2022Peer-reviewedImmunology