G. D. Brown

Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics.

This study identifies a specific stage of Aspergillus fumigatus spore development that activates dendritic cells to trigger allergic airway inflammation and shows antifungal drugs can reduce this process.

Within-Host Bayesian Joint Modeling of Longitudinal and Time-to-Event Data of Leishmania Infection

This paper develops a Bayesian joint model of longitudinal and time-to-event data for Leishmania infection in dogs, showing how immune factors and parasite load influence disease progression and mortality.

The pathogenesis of experimental Emergomycosis in mice.

This study establishes a murine model of Emergomyces africanus infection, showing that a T-helper type-1 immune response is protective against disseminated fungal disease.

Bayesian Multivariate Longitudinal Model for Immune Responses to Leishmania: a tick-borne Co-Infection Study

This paper develops a Bayesian state-space model to analyze immune responses to Leishmania infections in dogs, finding that co-infection and prior pathogen load influence disease progression.

Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing

This study shows fungal melanin blocks chemokine secretion and calcium fluxing in airway epithelial cells, reducing neutrophil recruitment to the airway.

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

This study identifies human Dectin-1 as a ligand for CLEC-2, showing its O-glycosylation enables it to function as a physiological ligand for immune regulation.

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

Maternal transfer of neutralizing antibodies to OspA after oral vaccination of the rodent reservoir

The paper shows that oral vaccination of mice leads to maternal transfer of neutralizing anti-OspA antibodies to pups via colostrum, with antibody persistence lasting up to 9 weeks.

Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity

The paper identifies a bacterial endosymbiont in Rhizopus microsporus that enhances fungal virulence by suppressing amoeba predation and macrophage clearance.

The RAB32/BLOC-3 dependent pathway mediates host-defence against different pathogens in human macrophages

This study identifies the Rab32/BLOC-3 pathway as a novel host-defense mechanism in macrophages that protects against bacterial and fungal pathogens.

Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwide

The paper analyzes the evolution of HIV-1 Env diversity across clades and regions, finding that inter-population diversity decreases while intra-population diversity increases due to conserved selective pressures.

Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls

The paper maps mannan-specific C-type lectin receptor (CTL) epitopes in fungal cell walls, revealing spatial, chemical, and phylogenetic diversity in immune recognition.

Comparisons of a Novel Air Sampling Filter Material, Wash Buffers and Extraction Methods in the Detection and Quantification of Influenza Virus

This study compares filter materials, wash buffers, and extraction methods for influenza virus detection, finding that polystyrene filters and specific buffer-extraction combinations yield the highest RNA recovery.

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis

This paper establishes an in vitro system to induce Titan cells in Cryptococcus neoformans, identifies bacterial peptidoglycan as an inducer, and shows that Titanisation is regulated and conserved across species.