Author

S. Itskanov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Organism:yeast· 1

Frequent Co-Authors

E. Park· 3 shared A. M. Van der Bliek· 1 shared A. Martorell Riera· 1 shared A. Turner· 1 shared B. Roach· 1 shared C. Forsyth· 1 shared C. Iriondo Martinez· 1 shared C. M. Koehler· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

E. Park

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

K. Wu, S. Itskanov, D. L. Lynch, Y. Chen, A. Turner, J. Gumbart, E. Park

This study defines the substrate recognition mechanism of Doa10 using structural and functional analyses in yeast, revealing a lateral tunnel and fence-like domains that facilitate substrate access.

bioRxiv · Jan 9, 2024 · PreprintBiochemistry

A common mechanism of Sec61 translocon inhibition by small molecules

S. Itskanov, L. Wang, T. Junne, R. Sherriff, L. Xiao, N. Blanchard, W. Q. Shi, C. Forsyth, D. Hoepfner, M. Spiess, E. Park

This study identifies a common binding site for diverse Sec61 inhibitors and shows how they stabilize the plug domain to block protein translocation.

bioRxiv · Aug 11, 2022Biochemistry

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

S. Itskanov, E. Park

This study reveals the stepwise gating mechanism of the Sec61 channel by Sec62 and Sec63 using cryo-EM structures of the translocation complex.

bioRxiv · Dec 14, 2020Biochemistry

Dynamin-2 controls phagophore maturation

A. Martorell Riera, C. Iriondo Martinez, S. Itskanov, J. Steffen, B. Roach, C. M. Koehler, A. M. Van der Bliek

This study shows that Dynamin-2 retrieves Atg9 from phagophores by fission, facilitating autophagy progression and phagophore maturation.

bioRxiv · Aug 19, 2019 · PreprintCell Biology