Author

J. Gumbart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Organism:yeast· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Acharya· 2 shared A. Pavlova· 2 shared D. Lynch· 2 shared Y. T. Pang· 2 shared A. Sali· 1 shared A. Turner· 1 shared B. Chait· 1 shared C. Akey· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

A. Acharya

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

K. Wu, S. Itskanov, D. L. Lynch, Y. Chen, A. Turner, J. Gumbart, E. Park

This study defines the substrate recognition mechanism of Doa10 using structural and functional analyses in yeast, revealing a lateral tunnel and fence-like domains that facilitate substrate access.

bioRxiv · Jan 9, 2024 · PreprintBiochemistry

Weak tension accelerates hybridization and dehybridization of short oligonucleotides

D. R. Hart, J. Jeong, J. Gumbart, H. D. Kim

This study measures how weak tension affects DNA hybridization and dehybridization rates using a DNA bow assay and single-molecule FRET, finding increased rates with tension for various sequences.

bioRxiv · Apr 19, 2022Biophysics

Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex

C. Akey, D. Singh, C. Ouch, I. Echeverria, I. Nudelman, J. M. Varberg, Z. Yu, F. Fang, Y. Shi, J. Wang, D. Saltzberg, K. Song, C. Xu, J. Gumbart, S. Suslov, , M. Rout

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

bioRxiv · Oct 29, 2021Biophysics

SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

Y. T. Pang, A. Acharya, D. Lynch, A. Pavlova, J. Gumbart

This study uses molecular dynamics simulations to analyze how glycans affect the opening dynamics and energetics of the SARS-CoV-2 spike protein, revealing their individual and collective roles in stabilizing the closed and open states.

bioRxiv · Aug 12, 2021Biophysics

ACE2 glycans preferentially interact with the RBD of SARS-CoV-2 over SARS-CoV

A. Acharya, D. Lynch, A. Pavlova, Y. T. Pang, J. Gumbart

The paper identifies differences in ACE2 glycan interactions with SARS-CoV-2 and SARS-CoV RBDs, showing N322 enhances SARS-CoV-2 binding while N90 may provide protection.

bioRxiv · Apr 29, 2021Biophysics