Author

W. Q. Shi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

S. High· 2 shared B. S. Hall· 1 shared C. Forsyth· 1 shared D. Hoepfner· 1 shared E. Park· 1 shared F. J. Salguero· 1 shared G. Zong· 1 shared H. Schneider· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

S. High

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

L. T.-H. Hsieh, B. S. Hall, J. Newcombe, T. A. Mendum, S. Santana-Varela, Y. Umrania, M. J. Deery, W. Q. Shi, J. Diaz Delgado, F. J. Salguero, R. E. Simmonds

This study shows mycolactone causes endothelial glycocalyx and basement membrane loss via Sec61-dependent mechanisms, leading to vascular dysfunction and tissue necrosis in Buruli ulcer.

bioRxiv · Feb 21, 2023Microbiology

A common mechanism of Sec61 translocon inhibition by small molecules

S. Itskanov, L. Wang, T. Junne, R. Sherriff, L. Xiao, N. Blanchard, W. Q. Shi, C. Forsyth, D. Hoepfner, M. Spiess, E. Park

This study identifies a common binding site for diverse Sec61 inhibitors and shows how they stabilize the plug domain to block protein translocation.

bioRxiv · Aug 11, 2022Biochemistry

Co-translational biogenesis of lipid droplet integral membrane proteins

P. Leznicki, W. Q. Shi, S. High

The paper shows that lipid droplet membrane proteins are inserted into the ER co-translationally via the EMC, with topology reorientation leading to hairpin loop formation.

bioRxiv · Aug 5, 2021Biochemistry

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

S. O'Keefe, P. Roboti, K. B. Duah, G. Zong, H. Schneider, W. Q. Shi, S. High

This study shows that ipomoeassin F inhibits the ER membrane translocation of SARS-CoV-2 spike, ORF8, and ACE2 proteins in vitro.

bioRxiv · Nov 24, 2020Biochemistry