Cell state and transcription factor modulation during extended ex vivo CD8+ T-cell expansion.
Yuan Lui, Edward M. Jenkins, Emily Zhi Qing Ng, Mateusz Kotowski, S. J. Mullin, Joseph Clarke, Simon J. Davis, Ana Mafalda Santos, Sumana Sharma
The paper uses bulk RNA-seq and single-cell RNA-seq data to study T-cell expansion and identifies FOSL1 as a transcription factor that promotes an effector phenotype, enhancing cancer-cell killing.
bioRxiv · Jul 17, 2024 · PreprintImmunology