S. J. Northall

Interaction of HelQ helicase with RPA modulates RPA-DNA binding and stimulates HelQ to unwind DNA through a protein roadblock.

This study identifies HelQ helicase's interaction with RPA, showing it enhances DNA unwinding through protein barriers but not abasic sites by destabilizing RPA-DNA binding.

Human CtIP forms a tetrameric dumbbell-shaped particle which binds and bridges complex DNA end structures for double-strand break repair

This study shows human CtIP forms a tetramer that binds and bridges DNA ends, facilitating resection for double-strand break repair.