Author

D. B. Wigley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. S. Dillingham· 2 shared O. J. Wilkinson· 2 shared A. C. H. Fung· 1 shared A. Cakebread· 1 shared A. K. K. Teo· 1 shared A. Martin-Gonzalez· 1 shared A. Mueller· 1 shared A. P. S. Kong· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

M. S. Dillingham

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Author profile →

3 papers

Recent·Most cited

Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

M. Wilkinson, O. J. Wilkinson, C. Feyerherm, E. E. Fletcher, D. B. Wigley, M. S. Dillingham

The paper presents structural and biochemical analysis of two phage proteins that inhibit or co-opt the bacterial RecBCD complex to evade host immunity.

bioRxiv · Sep 12, 2022Biochemistry

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

Molecular Metabolism · Oct 1, 2020Peer-reviewedCell Biology

Human CtIP forms a tetrameric dumbbell-shaped particle which binds and bridges complex DNA end structures for double-strand break repair

O. J. Wilkinson, A. Martin-Gonzalez, H. J. Kang, S. J. Northall, D. B. Wigley, F. Moreno-Herrero, M. S. Dillingham

This study shows human CtIP forms a tetramer that binds and bridges DNA ends, facilitating resection for double-strand break repair.

bioRxiv · Sep 5, 2018Biochemistry