Author

O. B. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

B. Kloss· 3 shared F. Mancia· 3 shared K. Kim· 2 shared M. Quick· 2 shared A. J. Noble· 1 shared A. K. Kossiakoff· 1 shared A. L. Rosario· 1 shared A. M. Raczkowski· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiochemistry

B. Kloss

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Author profile →

7 papers

Recent·Most cited

Structural and molecular basis of choline uptake into the brain by FLVCR2

R. J. Cater, D. Mukherjee, E. Gil Iturbe, S. K. Erramilli, T. Chen, K. Koo, N. G. Santander, A. R. Reckers, B. Kloss, T. Gawda, B. C. Choy, Z. Zhang, O. B. Clarke, S. W. Yee, A. K. Kossiakoff, , F. Mancia

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

bioRxiv · Oct 5, 2023Biochemistry

Mechanism of dual pharmacological correction and potentiation of human CFTR

C. Wang, Z. Yang, B. J. Loughlin, H. Xu, G. Veit, S. Vorobiev, O. B. Clarke, F. Jiang, Y. Li, S. Singh, Z. Rich, E. R. Menten, R. A. Grassucci, W. Wang, A. Mezzell, , J. F. Hunt

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

bioRxiv · Oct 10, 2022 · PreprintBiophysics

Architecture of the human erythrocyte ankyrin-1 complex

F. Vallese, K. Kim, L. Y. Yen, J. D. Johnston, A. J. Noble, T. Cali, O. B. Clarke

This study presents structures of the human erythrocyte ankyrin-1 complex, revealing its architecture and interactions with membrane proteins.

bioRxiv · Feb 10, 2022Biochemistry

Ion currents through Kir potassium channels are gated by anionic lipids.

R. Jin, S. He, K. A. Black, O. B. Clarke, D. Wu, J. R. Bolla, P. Johnson, A. Periasamy, A. Wardak, P. Czabotar, P. M. Colman, C. V. Robinson, D. Laver, B. J. Smith, J. M. Gulbis

The paper shows anionic lipids gate potassium conduction through Kir channels by interacting with the internal gate via fatty acyl tails.

bioRxiv · Sep 21, 2021Biochemistry

High resolution structure of the membrane embedded skeletal muscle ryanodine receptor

Z. Melville, K. Kim, O. B. Clarke, A. R. Marks

The paper uses cryoEM to solve high-resolution structures of RyR1 in liposomes, achieving 3.36 and 3.98 Å resolution for closed and open states, respectively.

bioRxiv · Mar 9, 2021Biophysics

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

Y. Z. Tan, L. Zhang, J. Rodrigues, R. B. Zheng, S. I. Giacometti, A. L. Rosario, B. Kloss, V. P. Dandey, H. Wei, R. Brunton, A. M. Raczkowski, D. Athayde, M. J. Catalao, M. Pimentel, O. B. Clarke, , F. Mancia

The paper presents the cryo-EM structure of AftD from M. abscessus and shows its interaction with ACP, revealing potential regulatory mechanisms.

bioRxiv · Dec 22, 2019Biochemistry

Structure-based analysis of CysZ-mediated cellular uptake of sulfate

Z. Assur Sanghai, Q. Liu, O. B. Clarke, E. Leal Pinto, B. Kloss, S. Tabuso, J. Love, M. Punta, S. Banerjee, K. R. Rajashankar, B. Rost, D. Logothetis, M. Quick, W. A. Hendrickson, F. Mancia

The paper investigates the molecular mechanism of CysZ-mediated sulfate uptake using structural and functional analyses.

bioRxiv · Apr 27, 2017Biophysics