Enhanced NK cell proficiency in solid tumors through antigen-specific memory via NKG2C/A-HLA-E/ABC recruited to tumors by CXCR2
Y. Sun, A. R. Furones, O. Gultekin, S. Khare, S. Y. Neo, W. Shi, L. M. Galceran, K.-P. Lam, R. DasGupta, J. Fuxe, S. Salehi, K. Lehti, D. Sarhan
This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.
bioRxiv · Mar 28, 2024 · PreprintImmunology