P. Majumder

CryoEM structure of QacA, an antibacterial efflux transporter from Staphylococcus aureus

The paper reports the cryoEM structure of QacA, an antibacterial efflux transporter, and provides insights into its conformational dynamics and function.

G4-Selective Ligand Induced Autophagy

This study shows that G4-selective ligands downregulate mTOR activity and induce autophagy by targeting G4 structures in the MTOR gene.

AP-4 regulates neuronal lysosome composition, function and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network

This study shows AP-4 regulates neuronal lysosome composition, function, and transport by controlling the export of lysosomal receptors from the trans-Golgi network.

A comparative study of stress responses elicited by misfolded proteins targeted by bipartite or matrix-targeting signal sequences to yeast mitochondria

This study compares stress responses in yeast mitochondria caused by misfolded proteins targeted to the IMS or matrix using different signal sequences, revealing compartment-specific adaptations.

PD-1 expression during acute infection is repressed through 1 a LSD1- Blimp-1 axis

This study shows that LSD1, recruited by Blimp-1, represses PD-1 expression during acute infection by removing activating histone marks and is necessary for remethylation of the Pdcd1 locus.

Dissection of protonation sites for antibacterial recognition and transport in QacA, a multi-drug efflux transporter.

This study identifies key protonation sites in QacA, a multidrug efflux transporter, revealing their roles in substrate recognition and transport of cationic compounds.