A. Gulati

PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

This paper develops human cervical Organ Chip models to study mucus production, host-microbiome interactions, and immune responses, showing they mimic in vivo conditions and respond to microbiome changes.

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

This study shows that PSMC3IP and MND1 depletion increases PARP inhibitor sensitivity in mitotic cells through impaired D-loop formation and homology-directed repair.

Distinct bile salt hydrolase substrate preferences dictate C. difficile pathogenesis

The paper identifies bile salt hydrolase (BSH) substrate preferences and shows they inhibit C. difficile by altering bile acid pools in CDI models.

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip

This paper develops a human vagina-on-a-chip model to study vaginal microbiome-host interactions and their effects on health outcomes.

Structural basis of inhibition of a putative drug efflux transporter NorC, through a single-domain camelid antibody

The paper reports the X-ray structure of NorC, a drug efflux transporter, in complex with a camelid antibody that inhibits its function by stabilizing it in an outward-open conformation.

Targeting DNA damage response and Replication Stress in Pancreatic Cancer

The paper identifies novel therapeutic strategies for pancreatic cancer by analyzing DNA damage response and replication stress in patient-derived cell lines.

Structural basis for the delivery of activated sialic acid into Golgi for sialyation

This study determines the crystal structure of a CMP-sialic acid transporter complexed with CMP, revealing its mechanism of CMP-sialic acid recognition and translocation across Golgi membranes.

Dissection of protonation sites for antibacterial recognition and transport in QacA, a multi-drug efflux transporter.

This study identifies key protonation sites in QacA, a multidrug efflux transporter, revealing their roles in substrate recognition and transport of cationic compounds.